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Posted by / 12-Mar-2020 06:08

Elucidating the role of

Previous loss of function studies, using mice deficient either for the receptor or for its ligand, FLT3L, have demonstrated that FLT3 signaling is required for lymphoid and also myeloid development.However, they have not been able to address the specific cellular stage of FLT3 requirement in the hematopoietic differentiation since the receptor was constitutively lost in the entire blood hierarchy and from the first HSC in the embryo.In this thesis, I have aimed to deepen our understanding of the regulation and differentiation of hematopoietic cells in the embryo, both in mouse and human. (More)B cells are essential cells that are part of the adaptive immune system with the capacity to produce antibodies against exogenous antigens.In this thesis, I have aimed to deepen our understanding of the regulation and differentiation of hematopoietic cells in the embryo, both in mouse and human.In the first paper, we have identified a new distinct B cell progenitor in mouse that is uniquely present in a narrow window of fetal liver lymphopoiesis and that possesses B/myeloid potential and gene identity.We have also shown that the tyrosine kinase receptor, CSF1R, marks and regulates this progenitor and that upon loss of CSF1R signaling, embryonic B lymphopoiesis was specifically impaired.

Overall, the papers included in this thesis highlight the need for studying embryonic hematopoiesis specifically, since regulatory requirements can change during ontogeny.

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Dyads did not discuss their lung cancer experience in terms of decision-making; rather, most articulated their role as following physician guidance.

Distinct lack of understanding about disease course, severity, and prognosis may constrain patient perception of the need for informed decision-making over the course of care.

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Among these, tyrosine kinase receptors and their cytokines have been shown to have an important role in adult lymphopoiesis regulation.