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In modern medicine they have been largely replaced by the benzodiazepines, primarily because they can induce tolerance, physical dependence and serious withdrawal symptoms.
Nevertheless, certain barbiturates are still employed as anticonvulsants (phenobarbital) and to induce anesthesia (thiopental).
They usually have limited therapeutic use, and some of the representatives are: Written by Dr.
Over-the-counter melatonin and prescription Ramelteon are examples.
Orexin Receptor Antagonism for Treatment of Insomnia Orexins sleep aids are new, so there is not as much data on their effectiveness and side effects.
However, early studies of orexins antagonists have found them to be well tolerated and to have few side effects.
The hope is that they will cause fewer side effects than other sleep aids on the market.
Some researchers are encouraged by the information known so far about this new class of sleep aid.
They also have hypnotic, anticonvulsant and muscle-relaxing activities, but do not exhibit analgesic action or antipsychotic activity.